Conolidine From Crepe Jasmine: A Safe and Effective Pain Relief Medicine

Imagine getting relief for pain directly from nature. That’s what Conolidine is made from the beautiful Crepe Jasmine! Conolidine isn’t just another supplement. It’s an alkaloid, which occurs naturally in plants. We’re uncovering what is one of the most intriguing research reports we’ve seen for Conolidine and its mysterious potential to provide safe, non-drowsy, non-addictive anti-inflammation relief.  With Conolidine, you can get relief without worrying about any side effects. Learn more today!

Details About Crepe Jasmine And Conolidine! 

Crepe Jasmine or Tabernaemontana divaricata

Botanical Overview: Tabernaemontana divaricata is a flowering plant in the Apocynaceae family. It's also called Crepe Jasmine or Pinwheel Flower.

Description: A shrub or tree that can grow up to 6 feet tall, Pinwheel Pine has flat shiny leaves that are deep red below with big fragrant white flowers that look like pinwheels. It usually produces lots of flowers during the warm months. However, it will bloom at random times in the year. Cultivars that produce double flowers are available.

Habitat and Distribution: Grows primarily in China, South Asia, and Southeast Asia in warm to tropical conditions.

Traditional uses: Crepe Jasmine is used in Ayurvedic, Chinese, and Thai medicine. It treats various conditions with different parts of the plant. Relieves rheumatic pain, headaches, and toothaches. Reduces inflammation in wounds.

Conolidine From Crepe Jasmine Pain Relief

Other Uses:

• Chronic Pain

• Joint Pain

• Muscle Aches

• Back pain

• Chemically Induced Pain

• Inflammatory Pain

• Acute Tonic Pain

• Neuropathic Pain

Conolidine: The Pain-Relieving Compound

Discovery and Source: Conolidine is a rare indole alkaloid naturally occurring in the bark of the Crepe Jasmine, or Tabernaemontana divaricata plant. Although the plant itself has been used for thousands of years. Conolidine is a unique chemical with pain-relieving effects. In 2011, researchers from The Scripps Research Institute discovered and synthesized it.

How Conolidine Works: A Non-Opioid Pathway to Pain Relief!

1. Targeting the Atypical Chemokine Receptor ACKR3 (CXCR7)

• The " Opioid Scavenger ": ACKR3 as a target for conolidine typical " opioid receptor, because its role is opposite from that of the classical opioid receptors. Which are responsible for pain relief when activated. Instead, ACKR3 is a " scavenger " receptor, and attaches to naturally produced opioid peptides in the body. Like endorphins and enkephalins and blocks them from interacting with the classic opioid receptors that cause pain relief. That way, the body's own natural pain-relieving system is inhibited.

• Effects of Conolidine: The chemical conolidine is active by interacting with the receptors ACKR3. Being thought to inhibit the action of the receptor as its “scavenger". " Thus by blocking the action of the receptor, it allows for the disposal of the endogenous opioid peptides. This effectively increases the availability of these natural pain-relieving compounds and allows the release of their analgesic effects.

2. Increasing Endogenous Opioid Availability

• Since the primary mechanism of action of conolidine is to release the " brake " on the body's natural opioid system. It will work indirectly to provide pain relief because it is not directly binding to classical opioid receptors, which is a huge difference from the more popular opioid drugs like morphine. This is why it is considered a non - opioid pathway even though it does affect the opioid system.

3. Other Potential Mechanisms:

• While the binding to ACKR3 has so far been the most well-supported mechanism, previous research has also looked into other potential targets. For example, some studies have suggested that conolidine might inhibit Cav2.2 calcium channels.

4. Why this is significant:

• Non-addictive potential: Because conolidine has no direct action on classical opioid receptors. It is hypothesized to have a lower risk of addiction, tolerance and respiratory depression. That is common in the development of traditional opioids.

• Benefits of natural pain relief: In addition to stimulating the body 's pain relieving chemicals, conolidine also has an equally natural effect.

• Drug targets: New drugs are being developed partly because of the finding of ACKR3 as a pain modulator. This opens up new ways to develop novel analgesics that work through this new pathway.

Unlocking the Crepe Jasmine's pain-relieving secrets!

Tabernaemontana divaricata, the botanical name for the vibrant Crepe Jasmine. It has long been enjoyed in the traditional medicine of Chinese, Ayurvedic, and Thai and perhaps even earlier traditions for many healing uses, including their traditional common use as a pain reliever. Humanity is now beginning to uncover the mysteries of this ancient wisdom. 

In particular through a new compound called conolidine, an indole alkaloid isolated from the bark of the plant. It also looks like, what’s most exciting is that conolidine appears to be a powerful painkiller via a non-opioid mechanism. Bypassing the great risk of addiction and side effects found with the more common opioid drugs. The atypical chemokine receptor ACKR3, also called CXCR7.  

Here, however, the compound acts as a "scavenger", binding to the body's natural pain-killing opioid peptides such as endorphins, which almost neutralize them. But conolidine appears to act as an inhibitor of ACKR3's scavenging action at the same time and in turn make these endogenous opioids. That is more available to do their job of doing it, which is to help ease the pain.

Conolidine : A Safe and Effective Pain Relief Medicine

Conolidine has great promise as a safe and effective pain medication, particularly in the context of chronic pain management. Studies show that it can provide analgesic activity in various pain models including chemically induced. And inflammatory pain without the typical adverse consequences of conventional opioid drugs respiratory depression, constipation, tolerance, and physical dependence. 

Conolidine’s novel mechanism of action is directed by interaction with the recently discovered opioid scavenger receptor. Increasing the availability of natural opioid peptides in the body positions it as a promising novel strategy to counter the current opioid crisis and provide a safer and quicker route to sustained pain relief.

Proleviate's Conolidine Medicine Is Effective For Pain Relief!

Proleviate produces a line of products, mainly a balm and drops with Conolidine and PEA (Palmitoylethanolamide) for both fast-acting and long-lasting pain relief. These products are sold for various purposes, including muscle and joint pain, chronic pain, and better sleep.

Key Ingredients of Proleviate's Products and Their Benefits:

Conolidine:

• Proleviate states that Conolidine is one of its active ingredients.

• Conolidine is an indole alkaloid derived from the bark of the shrub Tabernaemontana divaricate or crape jasmine. Traditionally used in Chinese, Ayurvedic, and Thai medicine for pain and fever.

• Proleviate’s Conolidine analgesic products have all the benefits of opioids without the common side effects.

• It is referred to as a "novel non - opioid analgesic" and a "potential novel analgesic agent" for the management of chronic pain.

PEA (Palmitoylethanolamide):

• Proleviate also contains PEA as an active ingredient. Particularly noting that the liquid form may be less potent because of the addition of PEA.

• PEA is a natural fatty acid found in the body, egg yolks, and peanuts.

• It has anti-inflammatory, analgesic, and neuroprotective effects.

• PEA activates immune responses. It also inhibits mast cell activation and suppresses pro-inflammatory cytokines. This ability may be associated with activation of receptors that control pain modulation, such as TRPV1 channels and GPR55 receptors.

Super Antioxidants and Essential Oils:

• It also makes a proprietary blend of all these plant-based extracts. Saying the antioxidants help combat free radicals and stop their oxidation as well as essential oils. They are soothing and healing because they have anti-inflammatory properties.

Proleviate's Intended Uses: Proleviate products are "modern natural balms and drops that work in a minute, lasting for hours ".

• Muscle & Joint Pain: Including arthritis, fibromyalgia, tennis elbow, sciatica, bursitis, frozen shoulder, carpal tunnel, RSI, knee and neck strain, hip pain, and myofascial syndrome.

• Chronic Pain: Addressing acute and chronic pain.

• Improved sleep: Helping to improve the quality of sleep of people who have sleep disturbed by pain.

 Common types of pain include:

• Joint pain

• Nerve pain

• Neck pain

• Back pain

• Knee pain

• Foot pain

The Bottom Line! 

Conolidine from Crepe Jasmine is a very promising and potentially revolutionary natural compound that can relieve pain. Due to the unique ability of this natural compound to deliver powerful analgesic effects without actually acting on any opioid receptor. The results of which may be in the form of a powerful modulation of the body’s natural opioid system. It represents a truly revolutionary development for pain relief and the opioid epidemic in general.