Conolidine: An Alternative natural Pain Relief to Replace traditional Painkillers

Do you suffer from daily pain and find yourself relying on over-the-counter drugs? Otherwise known as prescription painkillers. But why this, try a different route for your pain relief. Conolidine, a powerful alkaloid that comes from the Tabernaemontana divaricata plant. This is emerging as a promising alternative drug. More importantly, it’s a natural compound that could point the way to hopeful treatment for those looking for alternative painkillers. You don't need to face any side effects associated with lots of prescription drugs. Let’s take a look at this topic further.

What Are The Problems with Traditional Painkillers?

Addiction and Dependence: Opioids are notoriously addicting and over time use can result in physical dependence. Also, you can tolerate addiction, even when properly taken.

Respiratory Depression: Traditional pain killers can slow down and even stop breathing, which is quite a common cause of fatal overdose. Higher doses or with other drugs like alcohol increase the risk.

Tolerance: Oftentimes during use the body gets used to the medication and will need to use more to get the same level of pain relief. That can increase the risk of side effects.

Lack of Efficacy for Pain: For some types of pain, traditional pain relievers opioids especially may become ineffective. This can’t address the source of the pain.

Severe Side Effects: Side effects include nausea and vomiting, constipation and drowsiness. That can lead to constipation and hormonal imbalances.

Gastrointestinal Issues: Traditional painkillers can irritate the stomach lining and cause ulcers. Also, bleeding in the stomach and other conditions in the GI tract. It causes increased risk with age, high doses and long-term use.

Hepatotoxicity: Taking overdose amounts of acetaminophen will cause serious damage to the liver and sometimes death. Acute liver failure led by acetaminophen overdose is, in fact, the highest in the United States.

Hidden Doses:  Acetaminophen is one of the most common ingredients in many OTC and prescription drugs. For example cold and flu remedies or combination painkillers. It can be easily overdosed if the user does not pay attention to all the labels.

Conolidine An Alternative Natural Pain Relief

Is Conolidine An Alternative Natural Pain Relief to Replace Traditional Painkillers?

Conolidine is a natural indole alkaloid obtained from the shrub crepe jasmine. It's a potential pain reliever that scientists are looking into at the moment. Some early work indicates that it might be a promising new form of pain relief because of its unique mechanism of action. Unlike traditional opioids which bind to and activate classical opioid receptors in the brain and neck area. Conolidine appears to have a different receptor ACKR3 (which acts as a “scavenger” for opioid peptides produced naturally in the brain. 

Blocked by ACKR3, conolidine prevents it from trapping these opioid peptides released. Which will then increase their availability and lead to alleviation of pain. The data suggest that conolidine can be an effective analgesic and be comparable in effectiveness to morphine in relieving some types of pain. However, it seems to have many of the adverse side effects that opioid drugs have including addiction, respiratory depression, constipation, and sedation. To be clear, Conolidine seems to be an interesting tool in pain treatment.

Why Conolidine Can Replace Traditional Painkillers?

Fundamental Shift in Mechanism

Conolidine’s mechanism of action is different from that of opioid receptors; anorectic drugs work by attaching to opioid receptors, which signal pain signals directly to the brain. Conversely, conolidine works by a novel non-opioid signaling pathway. That’s why it’s effective without the much-publicized risks that opioids pose.

Elimination of Addiction and Dependence

As you know, the opioid epidemic is on a global scale because of the extremely addictive nature of these drugs. Conolidine does not activate the same reward or reward-seeking pathways in the brain as opioids. It provides a truly non-addictive alternative to medication use in patients who need long-term pain management.

No Risk of Respiratory Depression

The most common mechanism from an opioid overdose is respiratory depression, depressing the body’s urge to breathe. Conolidine does not cause this. This one fact makes it much safer in an emergency situation or in patients who have a risk of overdose.

Bypassing Common Side Effects

Nausea, vomiting, and severe constipation are severe side effects of traditional opioid use that may affect a patient’s ability to function. In the likelihood that they will adhere to treatment. Because conolidine does not have opioid receptors in the digestive tract, its side effect profile is a cleaner one, and hence it is more palatable.

A New Approach to Pain Modulation

Instead of doing its job directly by reducing the pain, conolidine seems to work by discharging the body's own natural pain relievers. It seems to be blocking one of the receptors called ACKR3 which normally " scavenges ". Then gets rid of all of the body's natural opioid peptides, this includes endorphins. Thus by inhibiting ACKR3, the body can still use its own natural painkillers to provide relief.

Potential for Long-Term Efficacy

Long term opioid treatment in patients tends to lead to a decrease in tolerance. Due to the use of increasingly high doses over time and increased risk of side effects and dependence. Early research suggests that conolidine may not increase tolerance in patients. Thereby providing a stable and effective treatment for pain without the need for increasing doses.

Targeting Multiple Pain Pathways

In addition to modulating ACKR3, some studies suggested that conolidine may also inhibit calcium ion channels. This suggests a multi-targeted pain relief strategy which would involve targeting multiple aspects of the pain signaling pathway. This dual action may make it more effective in terms of treating a wider range of pain conditions.

Reduced Risk of Overdose

Given the mechanism of action of conolidine unlike opioids which in turn would do respiratory damage. It would not cause a fatal overdose the way opioids would. This makes it an undoubtedly far more safe drug to give in a medical setting. A much less likely cause of accidental or intentional overdose in patients.

The Proleviate Approach For Natural Pain Relief to Replace Traditional Painkillers!

For those concerned about taking these medicines and getting addicted, as well as for asthma and respiratory problems. 

Proleviate is a very safe alternative to the conventional painkillers in terms of ingredients:

• Conolidine: 

This really is one of the most revolutionizing safe painkillers! It truly is not an opioid analgesic, this is really a non-opioid analgesic that actually doesn't work like many traditional opioid analgesics. That means you get decent pain relief without getting hooked on it or finding yourself with respiratory depression. This really is a game-changer in how the treatment of pain is taken.

• PEA (Palmitoylethanolamide): 

PEA (unnatural fatty acid amide) works to relieve the inflammation response in the body by reducing inflammation. Also, relieving pain and discomfort from the inside out. It’s the ideal addition to Conolidine’s fast acting relief.

Nature's Defense for Your Body

Proleviate is more than a pain reliever, it is an entire holistic wellness solution. This includes our advanced balm and drops that are infused with a proprietary blend of high quality plant-based extracts and essential oils that are known for their:

• Anti-inflammatory Properties: 

The essential oils in Proleviate have been chosen for their soothing and healing properties. They help to reduce the inflammation at the source of your pain.

• Super Antioxidants: 

The proleviate product has antioxidants that have been shown to “scavenge” free radicals. This will help to prevent and slow the damage cells can do due to oxidation. Also, help your body with its natural defense and healing mechanisms.

You can get Fast-Acting Relief for a Wide Range of Conditions With Conolidine Proleviate's products! 

Thousands of people are using Proleviate for relief from a wide range of conditions such as: Muscle, Joint pain, Arthritis, Fibromyalgia, Sciatica, Back and Neck pain, Knee and Foot pain, Nerve pain & more. Proleviate products work fast & last for hours to help you quickly get back to what you love, the things you love. Whether you’re having a hard time with pain or are having trouble falling asleep because of discomfort. Proleviate is the safest, natural and most effective solution for all of your painful problems. Our innovative balms & drops can give you the relief you need to get back to the things you love and live a quality life.

The Bottom Line! 

You may be wondering, how can I manage my pain without compromising my overall health? Well, the answer may not be about searching for relief but rather about living a healthier life. Conolidine is a major leap forward in natural pain relief and is a powerful, nutrient-rich plant compound. That works within your body’s natural system to promote healthy growth. As you can see there are many benefits of choosing conolidine. So, it's time to embrace your wellness as the new normal.