Does Conolidine Relieve Pain?
- info9717004
- Jul 6
- 5 min read
Pain management has never been easy. One reason so many people have chronic pain is the severe side effects of opioid painkillers. Now a new study believes that conolidine, the alkaloid found in the herb Tabernaemontana divaricata, may be the secret to its success. A recent study finds that this intriguing alkaloid may offer powerful pain-relieving effects. Best of all it may be doing all of this without having the addictive properties or potential side effects of more commonly prescribed painkillers. Does Conolidine Relieve Pain? Here’s what it could do.
From Plant to Pain Solution: The Story of Conolidine
Imagine a world where treatment for pain does not have the burden of addiction and it has no side effects. This is a reality, not just a fantasy. Thanks to a remarkable discovery: conolidine. A naturally occurring alkaloid derived from Tabernaemontana divaricata. This plant has had a fantastic history. For centuries, the plant has been used in traditional Chinese, Ayurvedic, and Thai medicine to treat various diseases. Now, modern research is starting to uncover its extraordinary power.
Scroll down for videos. Conolidine is an effective pain reliever. It works differently from opioids. Because it does not target the same receptors, that means less risk. There is less risk of dependence. There is a lower risk of life-threatening side effects. Researchers are excited they believe that conolidine could be the future of pain management. A safe, effective, natural alternative, a breakthrough for millions suffering from chronic pain. Coming from plant to pain solution and it's incredible.
Does Conolidine Relieve Pain? Know The Actual Answer!
Yes, there is increasing evidence that conolidine does work. Conolidine is an extracellular metabolite of a naturally occurring compound with potent analgesic properties. In fact, there has been considerable evidence of this in the past few years in research that it does indeed have potent analgesic properties.
This is excellent news for the field of pain management, particularly given its definite global implications. Its primary role is against the atypical chemokine receptor ACKR3, 0also known as CXCR7. This is the "scavenger" receptor. That means that by binding to that receptor, conolidine prevents it from trapping the body's natural opioid peptides, such as endorphins. That means they will become more available to the body.
Since these peptides can then interact with the classic opioid receptors, they tend to help with your pain. This unique mechanism could offer real benefits to chronic pain management. Specifically, conolidine could keep you from getting addicted, developing tolerance, or even getting respiratory depression. All of which can be problems with traditional opioids. Conolidine is a safe and effective treatment for pain.
How Conolidine Targets Pain Without Opioid Risks?
Targets the "Opioid Scavenger" Receptor (ACKR3/CXCR7)
Conolidine works primarily by targeting the atypical chemokine receptor 3 (ACKR3) receptor. Also known as CXCR7 receptor.
Increase Availability To Natural Opioid Demand
ACKR3 acts as a "scavenger " receptor that captures and internalizes its natural pain-relieving peptides endorphins and enkephalins. Binding to ACKR3 conolidine blocks its action as a scavenger.
Does Not Directly Blind To Classical Opioid Receptors
Conolidine is an opioid pain reliever that has a different effect profile than other opioids. Not directly bound to Classical Opioid Receptors, Conolidine does not specifically bind to the mu-opioid receptors (MORs). Due to its use of traditional opioids, which are involved in the opioid-addictive effects of the drug, respiratory depression. Also, severe constipation due to their interaction with primary opioids.
Enhances Endogenous Pain Relief
With the release of natural opioid peptides, the conolidine allows them to interact more efficiently with the classical opioid receptors in the body, thereby increasing the intrinsic pain modulation system within the body. In return, this results in pain relief without directly influencing the pathways that cause the effects of opioids.
Conolidine does Not Induce Opioid Side Effects
Because it does not bind directly to classical opioid receptors, it does not affect the mechanisms that cause:
Addiction and physical dependence.
Tolerance (requiring higher doses over time).
Severe constipation.
Nausea and vomiting.
Respiratory depression (slowed breathing).
Potential calcium channel modulation
Some research claims that conolidine may inhibit Cav2.2 calcium channels, which would also offer another non - opioid strategy to alleviate pain.
What Current Research Says About Conolidine's Efficacy?
Recent analysis provides valuable insights into how Conolidine might relieve pain. Studies of today consistently demonstrate potent analgesic activities. It acts in almost all types of pain. This includes acute, inflammatory, and chronic pain. One significant breakthrough in recent years has been the discovery of the drug's target.
This leads to its practical analgesic effect. Importantly, it does not involve the adverse side effects of painkillers like opioids. So, it is a safe, non-sedating alternative to what many people take. Scientists still work hard to discover synthetic analogues of conolidine.
Some of these analogs show even more activity than that. That's only fueling their promise for clinical use. The results are positive. Conolidine has the potential to transform how pain management is implemented. It promises to be a safer and highly effective option for millions of people who take it daily.
How Proleviate's Conolidine Products Relieve Pain?
Proleviate offers its Conolidine product primarily in two forms:
Proleviate Balm: The topical application is designed for local pain relief of muscle and joint aches, as well as other types of pain.
Proleviate Drops: These are likely to provide systemic pain relief. Also, state they can be applied topically.
Both of these products contain Conolidine. This one is also referred to as the active ingredient that allows them to relax the muscles.
Increasing Natural Opioid Availability for Pain Relief:
Conolidine binds to ACKR3 and essentially inhibits or modulates ACKR3's activity. Which in effect prevents ACKR3 from binding to a naturally occurring opioid peptide in the body. Allows more of this naturally occurring opioid peptide to reach its target receptor, classic opioid receptors. By allowing more of the body's natural pain-relieving compounds to reach their target receptors. Conolidine indirectly stimulates the body's intrinsic pain control mechanism, leading to analgesic pain-relieving effects.
Non-Classical Opioid Mechanism and Reduced Side Effects:
One obvious point Proleviate mentions is that Conolidine does not directly activate classical opioid receptors. That is probably one of the most significant differences between prescription opioid pain medications. Because it does not directly activate these receptors, Conolidine may offer pain relief with the less common and severe side effects of conventional opioids. Such as- addiction, tolerance, respiratory depression, nausea, constipation, and, most likely, dependence. That makes it a rather appealing "non-opioid analgesic".
Pain Conditions Proleviate Aims to Address!
Proleviate claims its products can help with a wide range of conditions, including:
Arthritis
Fibromyalgia
Tennis Elbow
Sciatica
Bursitis
Frozen Shoulder
Carpal Tunnel
Acute and Chronic Pain
Hip Pain
Myofascial syndrome
Back Pain
RSI (Repetitive Strain Injury)
Knee and Neck Strain
Joint Pain
Nerve Pain
Foot Pain
The Bottom Line!
Conolidine is not the same as a pain reliever. That is because Proleviate's Conolidine helps enhance your body's pain-fighting mechanisms, opening up corresponding endogenous painkillers. This innovative method enables effective pain relief without the standard detriments of addiction and unpleasant side effects. Inherit the future of natural, responsible pain relief with Proleviate.
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