How Does Conolidine Work?

Let go of what you think is the best way to make pain go away. For centuries, little-known plants called "crepe jasmine" have played a key role in traditional healing methods. Now there's good news for you: scientists are finally finding what makes this plant so powerful: its compound, conolidine. 

This isn't a new painkiller. Conolidine works excitingly. It makes the pain go away without the risks associated with much of the modern-day stuff. So why is it so exciting? Hear the story behind this compound, and find out how it could change how we deal with pain.

What Is Conolidine?

The tropical blooming shrub Tabernaemontana divaricata (also known as "pinwheel flower" or "crepe jasmine") has the majority of its conolidine, a naturally occurring chemical (indole alkaloid), in its bark. This herb has historically been used as an aphrodisiac in traditional Chinese (Ayurvedic) and Thai medicine for pain and fever.

An essential aspect of what makes conolidine so interesting is that it can be a non-opioid analgesic, that is, it may be used as a pain reliever without most of the adverse effects associated with opioid prescription drugs ( morphine among them ) such as addiction, tolerance, respiratory depression, nausea, and constipation.

Tabernaemontana divaricata

What Are The Advantages Of Conolidine?

Non-Addictive Potential

This is probably the most crucial advantage because, unlike opioids (which are highly addictive, highly dependent, and frequently lead to withdrawal symptoms), conolidine seems to be able to circumvent the classical opioid receptors responsible for its addiction features. In this sense, it may be a promising long-term pain treatment drug for people with substance use disorder.

Novel Mechanism of Action

To relieve pain, Conolidine is thought to work via a different type of opioid receptor (ACKR3/CXCR7): the "scavenger" of these natural pain-relieving opioid peptides. When the "scavenger" receptor of conolidine is blocked, the available natural opioid peptides could thus be increased and the pain could be relieved. As its name implies, the new method opens a new avenue in treating pain.

Potential for Chronic Pain Management

Although conolidine is not addictive and exhibits a good antidote effect profile it appears that it would be very useful as a treatment for chronic pain conditions in which analgesics must be used in longer durations (OPIOD treatment in chronic pain is problematic due to the generation of tolerance and dependence).

Reduced Tolerance

Typically, with repeated opioid use, the body will build up tolerance to the substance so that higher doses are needed to get the same level of pain relief ( this also means increased doses and higher risk for side effects ). The hypothesis is that conolidine will exhibit less or no tolerance development by some mechanism.

Natural Origin

Conolidine comes from a plant ( Tabernaemontana divaricata ) that has been used in traditional medicine for centuries. This might appeal to people who are looking for plant-based remedies.

How Does Conolidine Work?

The "Scavenger" Receptor (ACKR3): Your body makes its pain-relieving chemical called endogenous opioid peptides (often referred to as endorphins or enkephalins). These are actually your natural painkillers. ACKR3 functions as a "scavenger" or "trap" for these additional beneficial peptides. It binds to them and pulls them out of your bloodstream before they can reach and activate the classical opioid receptors (the ones that provide pain relief ). 

Conolidine binds to the Scavenger: Conolidine binds explicitly to this ACKR3 "scavenger" receptor ( although crucially, it doesn't actually activate the classical opioid receptors ), but is bound to ACKR3, which, by binding to the receptor, blocks the action of ACKR3.

Increased the natural painkillers: ACKR3 block is from consolidation, and now it can't "trap" your body's natural opioid peptides. It can release more of these natural pain-relieving substances that are circulated and then attach to their intended targets ( classical opioid receptors ).

Pain Relief without the Side Effects of Opioid: Your natural opioid peptides attach to the classical opioid receptors and start the chemical process that leads to pain relief because conolidine itself doesn't really activate the receptors. It has none of the nasty side effects you see with opioid drugs, such as addiction tolerance and dangerous respiratory depression.

Reason To Buy Conolidine Products From PROLEVIATE!

1. Harnessing Conolidine's Unique Power

Proleviate does all of this by offering products based on conolidine ( a new compound found naturally ). So here's the thing: you aren't just buying another pain reliever; you're getting something that turns into a novel painkilling mechanism, hopefully, one that doesn't have the serious side effects you get with all of the other types of painkillers out there ( such as opioids ). It's giving your body the power it needs to fight off pain.

2. Rapid and Permanent Relief – "Works Fast and Lasts for Hours"

Your active lifestyle demands solutions that work. Proleviate was developed with immediate, long-term relief in mind so you can get "BACK TO WHAT YOU LOVE" in a fraction of the time. This allows sufficient time for the medication to take effect instead of administering it repeatedly, directly leading to you spending more time enjoying life and less time "kicking back" due to discomfort.

3. Comprehensive Pain Management

Proleviate is not a one-trick pony. It's meant to be used for a wide range of discomfort; it helps with "muscle and joint aches, chronic pain," and it actually helps "improve your sleep." It's a holistic approach to not only pain but also its effects on overall health.

4. Nature's Defense for a Myriad of Ailments

Explain how it helps in a wide range of conditions and point out the product's IMDB rating of "Arthritis, Fibromyalgia, Tennis Elbow, Sciatica, Bursitis, Frozen Shoulder, Carpal Tunnel, Acute and Chronic Pain, Hip Pain, Myofascial syndrome, Back Pain, RSI, Knee and Neck Strain and many others."

5. Thoughtfully Blended with Essential Oils

The "essential oils" that make up Proleviate are chosen for their soothing and healing properties, as well as their anti-inflammatory and other valued properties. This carefully selected blend adds the therapeutic benefits of conolidine to the overall treatment.

6. Quality and Trust with FDA-Approved Ingredients

As you declare "FDA-approved Ingredients along with a proprietary blend of the highest quality plant-based extracts," it gives you confidence. From the look and feel of the product you're using, you know you're going to "get back to living a quality life!"

The Bottom Line! 

Conolidine is a genuinely different drug because it does not directly affect the receptors responsible for addiction to opioid pain medications and the many side effects of these drugs. This means you CAN feel perfect about the effectiveness of Conolidine by benefiting from your innate defenses. It's also a promising step toward a more natural and well-tolerated pain relief compound.