How Does Conolidine Natural Morphine Reduce Pain?

Discover the mechanism behind conolidine, a natural alkaloid elicited by the plants Tabernaemontana divaricata. Conolidine has been nicknamed ‘nature’s morphine’ for its excellent pain-relieving action. Now it appears that conolidine acts differently from other opioid drugs. They primarily target the opioid receptors in the brain. Instead, conolidine seems to work via a different neurobiological pathway in the body. It offers an uncomplicated yet effective treatment method for reducing pain. It’s truly wonderful to know that this natural pain reliever is so safe and effective!!

The Science Behind the Pain Relief: Conolidine’s Unique Mechanism of Action!

The mechanism of action for conolidine is quite different from classical opioids. Instead of directly targeting classical opioid receptors, thereby leading to addiction and respiratory depression. It interacts with other receptors in the brain. Researchers have recently demonstrated that conolidine targets the atypical chemokine receptor 3 (ACKR3). 

Which is a “scavenger” for the body’s own “natural painkilling” opioid peptides, endorphins and enkephalins. With this interaction bound to and inhibited, conolidine prevented ACKR3 from trapping these “natural” opioids. Therefore allowed their own painkillers to remain in the body so that they would continue to bind to the classical opioid receptors and have an analgesic effect.

This type of indirect modulation of the opioid system represents a landmark discovery. Because it potentially opens up the door to enhancing the natural mechanisms that treat pain in the body. Without actually starting to activate the receptors that produce some of the most toxic effects of opioids. Much remains to be learned about exactly what conolidine does. But it does appear that it could lead to new avenues in the development of safer and less addictive opioid drugs.

Conolidine Natural Morphine For Pain Relief

How Does Conolidine Natural Morphine Reduce Pain?

Modulation of the Atypical Chemokine Receptor 3 (ACKR3)

This is the most crucial point and well-researched. Contrary to standard opioids that directly activate classic opioid receptors (mu, delta, kappa. Conolidine binds to another receptor, called ACKR3 (see CXCR7). ACKR3 is an “atypical” opioid receptor that does not trigger the same G-protein signaling cascade as classic opioids.

Opioid Scavenging Inhibition

ACKR3 is a crucial “scavenger” or “decoy” of the body’s own natural opioid peptides, endogenous opioids, such as dynorphins and enkephalins. It traps and removes these naturally occurring pain relievers, thus effectively suppressing their pain-relieving abilities.

Increased Availability of Natural Opioids

By binding to and modulating ACKR3, conolidine prevents it from scavenging these endogenous opioids. Thereby increasing the concentration of the body’s painkillers. Also, allowing them to more readily bind to and activate the classical opioid receptors. The effect of pain relief is thus accomplished indirectly.

No Direct Activation of Classic Opioid Receptors

A critical difference between conolidine and similar drugs such as morphine is that it is not an agonist with the classic opioid receptors. Hence, it does not trigger the G-protein activation called euphoria, addiction, and respiratory depression common with conventional opioids.

Lack of Addictive Properties

Because conolidine works by avoiding the classic opioid receptors. It does not activate reward mechanisms in the brain that are responsible for addiction and dependence. It is therefore an up-and-coming candidate for chronic pain relief with no risk of opioid use disorder.

Inhibition of Calcium Channels

Some research has also suggested that conolidine may have another mechanism of action via inhibition of voltage-gated calcium channels, the Cav2.2 channel. Which is a pathway that other non-opioid pain relievers target. Also, this is believed to contribute to its overall analgesic effect by inhibiting the transmission of pain signals.

Anti-Inflammatory Effects

Conolidine has been used for centuries as a remedy for inflammation and fever in traditional Chinese, Ayurvedic, and Thai medicine. While it is not yet known how conolidine works in part due to the lack of crystal structure. Reducing inflammation may play a role in the relief of pain, particularly chronic and inflammatory-induced pain. 

Effectiveness in Both Acute and Persistent Pain Models

Unlike some analgesics which have a narrow target group, such as opioids. So, conolidine is effective in a broad range of systems for both acute and chronic pain, persistent pain. In models of chemically-induced pain, acute pain, mimicking drug effects, and inflammatory pain, which can lead to persistent pain. This is an advantage for conolidine as it suggests that its mechanism of action is sufficiently broad to tackle the various underlying causes of pain. From tissue damage at the pain stimulus, to longer-term inflammatory responses.

Empower Your Body’s Natural Painkillers With Conolidine!

Your Body’s Natural Pain System: Pain is a natural painkiller by your body. You produce your in-built pain relievers called endogenous opioids like endorphins and enkephalins. These molecules were intended to attach to specific “classic” opioid receptors in your central nervous system and then decrease your perception of pain.

Conolidine’s Role: When you give conolidine to your body, it’s not trying to compete with whatever painkillers you have naturally. It is specifically targeting and binding to the ACKR3 “scavenger” receptor.

Disabling the Scavenger: By binding to ACKR3, conolidine effectively inhibits the ACKR3 from being able to " scavenge” your natural opioid peptides. It basically takes the " scavenger " out of the equation.

Pain Relief Without Opioid Side Effects: You’re not kidding me when I say that the increased activity of your natural opioids on these target receptors gives you much pain relief. The way conolidine works is through an indirect mechanism. It does not directly activate the classic opioid receptors; therefore it doesn’t have the addictive, dependence, respiratory effects of the more common opioid prescriptions.

Proleviate's Conolidine Products For Reduce Pain!

Proleviate offers two primary product types: a balm and drops.

For the Balm: The Proleviate balm is intended for topical application. So you apply a very small amount directly to the area of pain, like-joint, muscle, etc.. Then rub it into the skin until it has fully absorbed into the skin. It’s designed for both quick relief and long-lasting effect.

For the Drops: The drops are generally taken sublingually under the tongue or combined with something in the drink. So that the active ingredients are absorbed into the bloodstream.

Why Use Proleviate's Conolidine Products?

There are several compelling reasons to choose Proleviate:

• Unique Active Ingredients: The actual selling point of the product is the combination of Conolidine and Palmitoylethanolamide (PEA). Conolidine is a powerful natural pain reliever that works without the addiction risks associated with opioids. PEA is an anti-inflammatory drug used to help control the body’s pain response.

• Wide Range of Conditions: Proleviate is used for many different conditions, such as arthritis, fibromyalgia, sciatica and acute and chronic pain.

• Fast and Long-Lasting Relief: The product is designed to work quickly and provide sustained pain relief for hours.

• Natural and Safe Formulation: Proleviate is an extract of natural plant sources, extracts, and super antioxidants. That provides an alternative to synthetic drugs without steroidal activity. Antioxidants also reduce the oxidative stress level.

• Improved Sleep: Probably the biggest benefit is that it can help you get better sleep, often disrupted by pain.

The Bottom Line!

Conolidine helps to relieve pain by activating the body’s own pain-killing system. The chemical conolidine blocks an “atypical” receptor which can kill off the body’s own natural painkillers. This allows the body to use all of its own endogenous opioids. To treat pain effectively without becoming addicted. Proleviate’s products with conolidine use their ability to harness this mechanism to provide all types of pain relief with natural and fast-acting relief.